A Target Restricted Assembly Method (TRAM) for Phylogenomics

While next generation sequencing technology can produce sequences covering the entire genome, assembly and annotation are still prohibitive steps for many phylogenomics applications. Here we describe a method of Target Restricted Assembly (TRAM) of a single lane of Illumina sequences for genes of relevance to phylogeny reconstruction, i.e. single copy protein-coding genes. This method has the potential to produce a data set of hundreds of genes using only one Illumina lane per taxon

Patient Engagement: The Impact of Electronic Patient Portal Use on Missed Appointments in Patients with Diabetes, a Retrospective Study

Background: This retrospective observational chart review evaluated the use of the MyChart® patient portal as a viable tool for engaging patients. Engagement was measured as fewer missed appointments (no-shows and same-day cancellations). Objectives: To determine who uses the MyChart® patient portal in a chronically ill population of adult patients with diabetes and assess the association of portal use with missed appointments. Methods: The medical records of adult patients (18-80) with a diagnosis of Type 1 and/or Type 2 Diabetes Mellitus (DM) were reviewed (N=7,795). The efficacy of the MyChart® patient portal at reducing missed appointments was assessed by comparing patients who use the portal (evidenced by two or more log-ins during the study period) to those who do not. Results: In this study, 43.7% of adult patients with diabetes used a portal account. Portal users were predominantly female, non-Black, married, non-smokers, and had at least one of the comorbidities often associated with diabetes (hypertension, hyperlipidemia, and/or obesity). Portal users were on average 58.8 years old. Use of the MyChart® patient portal was independently associated with a reduced no-show rate (4.7% for portal users compared to 12.4% for nonusers). However, when patients who activated a portal account during the study period were subjected to a within-subjects analysis, the mean missed appointment percentage was not statistically significantly different when patients had an activated portal account compared to when they did not. Thus, the portal may be a useful tool for engaging chronically ill patients but it is only one component to appointment arrivals. Conclusion: Conclusions from this study are limited given the retrospective design. Nonetheless, the findings suggest that the patient portal is effective at engaging chronically ill patients and thus warrants greater merit. The portal may also be a useful tool for reducing missed appointments in patients with chronic illness who would greatly benefit from appointment adherence. Future research should focus on testing the hypotheses generated in a prospective manner

Transport properties of room temperature ionic liquids from classical molecular dynamics

Room Temperature Ionic Liquids (RTILs) have attracted much of the attention of the scientific community in the past decade due the their novel and highly customizable properties. Nonetheless their high viscosities pose serious limitations to the use of RTILs in practical applications. To elucidate some of the physical aspects behind transport properties of RTILs, extensive classical molecular dynamics (MD) calculations are reported. Bulk viscosities and ionic conductivities of butyl-methyl-imidazole based RTILs are presented over a wide range of temperatures. The dependence of the properties of the liquids on simulation parameters, e.g. system size effects and choice of the interaction potential, is analyzed

On Testing for Impropriety of Complex-Valued Gaussian Vectors

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Simulation of improper complex-valued sequences

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Kinematics of complex-valued time series

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Mobile travel services: A three-country study into the impact of local circumstances

In this paper we explore the difference in acceptance patterns of mobile services that are related to travelling in three countries: Finland, The Netherlands and New Zealand. The objective of this paper is to understand differences in the use of Mobile Travel Services in three countries that differ with regard to national travel patterns. This paper also contributes to the discussion of the relevance of the Technology Acceptance Model for mobile applications by focusing on the importance of context characteristics, such as the degree of mobility of the user, the social situation people are in, and their need for social interaction. Based on surveys in the three countries as executed in 2009, we use structural equation modelling to find differences in patterns. The paper concludes that context factors have an impact on the relation between the core concepts as used in TAM and DOI approach, and that t here is a clear need for closer research in the moderating effect of physical (e.g. mobile and fixed context) and social context, as well as the need for social interaction. Moreover it is clear that country specific characteristics play a role in the acceptance of mobile travel services. As we pointed out in many of our research projects before the acceptance and use of mobile services requires deep understanding from individual, context and technology related characteristics and their mutual interactions

Mobile travel services: the effect of moderating context factors

This article has two objectives: (1) to draw an international comparison regarding the acceptance of mobile travel services in three countries with different profiles when it comes to travelling and mobile telecommunications, and (2) to extend relevant literature on mobile applications, more specifically travel services, by including context-related concepts, taking moderating factors like location, mobility of users, physical, and social context into account. Based on surveys that were carried out in 2009, structural equation modelling is used to identify differences in patterns in the use of mobile travel services and in the role of context-related variables. the conclusion of this article is that context-related factors, that is, mobility and (physical and social) context, have an impact on the relationship between the core concepts of technology Acceptance model (TAM) and Diffusion of Innovation (DoI) research. many studies on the acceptance and use of mobile services indicate that a deep understanding is needed of individual, context-related, and technological characteristics and the way they interact. this is also highly relevant to the travel industry, which wants to utilize the opportunities provided by mobile technology

Responsivity-based Criterion For Accurate Calibration Of Ftir Emission Spectra: Theoretical Development And Bandwidth Estimation

An analytical expression for the variance of the radiance measured by Fourier-transform infrared (FTIR) emission spectrometers exists only in the limit of low noise. Outside this limit, the variance needs to be calculated numerically. In addition, a criterion for low noise is needed to identify properly calibrated radiances and optimize the instrument bandwidth. In this work, the variance and the magnitude of a noise-dependent spectral bias are calculated as a function of the system responsivity (r) and the noise level in its estimate (sigma(r)). The criterion sigma(r)/r \u3c 0.3, applied to downwelling and upwelling FTIR emission spectra, shows that the instrument bandwidth is specified properly for one instrument but needs to be restricted for another